The Tailai basin is one of the known hydro-geological units containing strontium mineral water. The study on the genesis and distribution of strontium mineral water in the Tailai Basin can provide direction for the investigation and development of strontium-bearing mineral water in the future. On the basis of the division of different water-bearing rock groups in the Tale basin, water samples such as Karst water, fissure water, porosity water and surface water were collected in the basin. The hydrogeochemical characteristics of four types of water and the evolution of mineral water containing strontium were studied by mathematical statistics, ion ratio coefficient, correlation analysis, isotope analysis and hydrogeochemical simulation. The results showed that the four types of water showed the characteristics of calcium-rich, magnesium-rich, low-sodium, low-potassium and weak alkaline, and the main hydrochemical type of them is HCO₃.SO₄-Ca.Mg. The four types of water are closely linked and affected by some degree of evaporation and concentration. The Sr₂₊ concentration of Karst water and pore water in the central basin was high, while the concentration of bedrock fissure water and surface water was relatively low. The enrichment of Sr₂₊ in groundwater is mainly controlled by weathering dissolution of calcareous minerals such as calcite and dolomite, and affected by evaporation concentration to a certain extent, while the effect of cation exchange is relatively small.