Abstract：The Xiazhuang uranium orefield is an important uranium producing area in Nanling region, where there exist many ore deposits. To solve the much controversial problems of the origin of uranium and the ore-forming fluid, this research is focused on Sr, Nd and Pb isotopic geochemistry of the gangue minerals. The results show that the carbonate has rich radioactive lead. The lead and uranium mainly came from such granitic rock bodies as Maofeng granite. The compositions of Sr and Nd isotope show that the ore-forming fluid was mainly derived from the crust. The water-rock interaction between the ore-forming fluid and the basic dike rock during the upward migration of the ore-forming fluid and the precipitation of uranium formed the feature of binary composition of the gangue minerals.