Abstract：Through an integrated study of the data of uranium prospecting and exploration of the Shihongtan area in recent years, the paper systematically deals with the conditions of uranium deposit formation, such as the geological structure, depositional environment of ore-bearing rock series, distribution of sand bodies and development features of interlayer oxidation zones and also intensively studies the zoning of the ore-controlling interlayer oxidation zone, shapes, sizes and spatial distribution of orebodies, mode of occurrence of uranium, mineralization age and regularity of uranium mineralization. It further summarizes the regional formation conditions and ore prospects of sandstone-type uranium deposits. With progression of uranium prospecting, the southwestern margin of the Turpan-Hami basin is expected to become a large base of underground leaching sandstone-type uranium resources. This study has great significance for guiding prospecting for underground leaching sandstone-type uranium deposits in the Tianshan orogenic belt and similar areas.