Abstract：The continuous and periodic uplift of the Qinghai-Tibet Plateau since the Cenozoic is an important geological and environmental event during the evolution of the Earth. Especially the accelerated uplift of the plateau since the Late Cenozoic has made the Qinghai-Tibet Plateau and its peripheral areas become the highest step of continental China. The paper focuses on the uplift mechanism of the plateau through a detailed study of the composition and geometric and kinematic features of the Yulong-Haba block-a typical Quaternary rapidly and differentially uplifted area on the southeastern margin of the Qinghai-Tibet Plateau, and on that basis, the paper further studies the effect of the rapid uplift on geological hazards (e.g. earthquakes, avalanches, landslides and mudflows) and its controls on the occurrence and development of geological hazards. In the last, it is concluded that there exists a coupling relationship between the Earth's endogenic geological processes (rapid differential block uplift) and the exogenic geological processes (major geological hazards).