Abstract：Studies of the origin and evolution mechanism of groundwater in a type area not only have great significance for guiding the rational utilization and development of geothermal water resources but also provide important information for future geothermal resource exploration and evaluation. The authors studied the formation and evolution of geothermal water in the Dezhou hollow based on an analysis of the chemical composition, isotopes and hydrogeological characteristics of geothermal water in the area. The study shows that: the formation of the geothermal water is controlled by deep faults and basement structure in the area; the geothermal water is recharged by meteoric water, belonging to penetrating metamorphic water; the hydrochemical components consist predominantly of more soluble salts; and gas components are mainly marked by a mixture of components originating from the atmosphere, crust and mantle ultimate source is meteoric water—all these reflect the various hydrochemical processes in long-term run-off and deep circulation of groundwater.