Abstract：Selenium is an important trace element that has important influence on human health and its natural distribution is very uneven in topsoils in different areas in most cases. Recently, the development of natural Se-rich food according to the clues to local Se-rich soils is an important direction for the study of the agro-geological environment. Multi-target 1∶250000 regional soil geochemical survey in the Jiangsu Province shows that there exist relatively extensive Se-rich topsoils in some low mountains and hills in the Liyang-Yixing area, southern Jiangsu though selenium in topsoils is not rich in most areas of Jiangsu. According to the clue natural Se-rich tea has been discovered in the Liyang-Yixing low mountain-hill area. Preliminary study indicates that the formation of local Se-rich topsoils is related to some particular geological setting and that the soil environment producing natural Se-rich tea is relatively advantageous.