Abstract：The Neogene Zhujiang Formation and Hanjiang Formation of Panyu low uplift in the Zhujiang River mouth basin were divided into seven sequences on the basis of an analysis of outcrops, cores, logs, 3D seismic information and palaeobiologic characteristics. Some were assigned to obvious truncation or obvious overlapping and unconformity, and the others to gentle truncation or overlapping unconformity and conformity. Every third-order sequence was divided into system tracts and fourth-order sequences whose boundaries seem to be main flooding surfaces. Combined with the seismic attributes, the distribution and development of the depositional systems in the fourth-order sequences were revealed. Under paleogeomorphologic conditions and relative sea-level change control, the deltaic sand bodies in the lowstand tract system were distributed in the uplift-gentle slope-break zone. In the highland system tracts, however, they were distributed in or west of the uplift zone. This paper has divided the stratigraphic traps into four types with a prediction of their distribution. The lowstand sand bodies in the southeastern syndepositional fault slope-break zone and in the east have good hydrocarbon pool-forming conditions, which are hence considered to be favorable for the formation of structural-lithologic traps or lithologic traps.