Abstract：Based on regional geology, mineral geology and geophysics in combination with researches on the lithosphere and the earth's interior, the authors studied the variation of the crustal thickness of such geological bodies as block, orogeny, paleoplate suture zone (conjunction zone), uplift zone, depression belt and fault basin as well as that of the mass structure, Moho form and the lithospheric mantle in Southeast China continental area, carried out structural regionalism, discussed in detail the Yanshanian intracontinental orogenesis and the Himalayan continental extension as well as the process leading to the adjustment of lithospheric mass structure, and formulated an adjustment model for uplift and depression structural differentiation and crust-mantle mass structure. In addition, the thinning process of the crust at depth was investigated, and the dynamic mechanism of Yanshanian intracontinental orogeny as well as the large-scale ore-forming process in relation to the lithospheric mass structure was analyzed.