Abstract：In the investigation of groundwater contamination, the selection of monitoring target organic compounds is very important for the correct assessment of the real situation of groundwater contamination. According to organic compounds involved in the main standards currently used in the world, 29 items, which are not included in the “Guidelines of Groundwater Contamination Investigation” (CGS, 2006), are put forward in this paper in the hope that they can be wholly or partly considered in the groundwater contamination investigation in terms of the actual hydrogeological condition and the contaminant sources in the study area. It is suggested that more attention should be paid to the compounds with high mobility and high pathogenic risks.