Abstract：In this paper, the authors have studied zircon U-Pb chronology of the high-grade metamorphic rocks on the northern margin of the Central Tianshan Microplate. The dating results show that the detrital zircons from the meta-sedimentary rocks have recorded the variable magmatic thermal events from Archean to Neoproterozoic (3320 to 530 Ma), the magmatic zircons of the meta-igneous rocks were crystallized in late Neoproterozoic of 550 Ma, whereas the metamorphic zircons were formed in Devonian of 385-360 Ma. These data demonstrate that the Central Tianshan block was probably formed in Precambrian, and subsequently subjected to Varsican orogeny. Unlike the Tarim Craton with multi-stage Proterozoic tectono-thermal events, the Central Tianshan Microplate which occurred as a single continent did not experience the Precambrian metamorphism.