Abstract：The Aiding slope zone in southwest Turpan-Hami basin is a relatively stable tectonic unit, overlain by lower Jurassic Badaowan Formation,Sangonghe Formation and middle Jurassic Xishanyao Formation under warm and moist climate conditions. Middle Jurassic Xishanyao Formation is mainly a suite of coal-bearing fragment rock series of stream-stream delta facies. The mudstone-sandstone-mudstone texture of strata is well developed, and the sandstone body is mainly composed of feldspathic sandstone (conglomerate) and lithoclast sandstone (conglomerate) characterized by relatively low compositional maturity and texture maturity. Primary geochemical types of the rock are black and grey,with relatively strong reduction capability. The interlayer oxidation zone is widely developed in the formation and can be divided into 4 sub-zones, i.e., whole oxidation sub-zone, imperfect oxidation sub-zone, reduction-oxidation intermediate sub-zone and primary rock sub-zone．Sandstone type uranium mineralization is controlled fully by the interlayer oxidation zone and grows within the reduction-oxidation transitional zone．The Shiihongtan large-size interlayer oxidation zone type uranium deposit was recently found in the area. An integrated analysis of structural geological setting, target stratum for prospecting, interlayer oxidized zone, hydrogeological features, primary geochemical type of rocks and basic features of uranium ore in southwest Turpan-Hami basin indicates that prospecting vista of the interlayer oxidized zone uranium ore deposits is vast in the study area. The authors hold that Shiihongtan area should be regarded as the base area for further uranium exploration, and the main promising horizons are 1st and 3rd lithologic members of Middle Jurassic Xishanyao Formation, that Dican’er segment can serve as the prospective area for next reconnaissance survey, with the main promising horizon being 3rd lithologic member of Xishanyao Formation, and Baizuishan and Baxiankou segments can serve as the further pre-survey prospective areas, with the promising horizons being 2nd and 3rd lithologic members of Xishanyao Formation.