Abstract：The Yunnan-Guizhou-Guangxi metallogenic area is one of the most important areas for gold exploration. In recent years, gold prospecting has made some breakthrough in this area. Based on collecting data in such aspects as geology, geophysics, geochemistry, remote sensing and heavy minerals, the authors established a geological spatial database. Through a study of the ore-controlling geological conditions and a summarization of metallogenic regularity, a model of prospecting and prediction was formulated. On such a basis, the authors chose 57 kinds of indicative information covering 6 classes to delineate the information anomalies by using the information computation method of “Deposit Position Indicating System”. Combined with geological, ore and geochemical data, the authors delineated and evaluated the prospecting area.