Abstract：The Denggezhuang gold deposit is one of the most typical quartz vein gold deposits in the Muping-Rushan metallogenic belt in Jiaodong peninsula, and hence it has great academic significance and economic value. Ore bodies are located in the Kunyushan rock mass close to the contact zone between Jingshan Group metamorphic rocks and Kunyushan rock mass. Wall rock alterations of the ore deposit are relatively well developed, characterized by multiple stages and significant zonal structure. Ore bodies are controlled by the NNE-trending sub-fractures west of Jinniushan fracture zone. Based on a study of the “three in one” ore-forming model, the authors hold that the formation age of the vein rock is the same as the ore-forming age, and this vein rock and early Cretaceous magmatic rock are respectively Ⅰand Ⅱ grade ore-forming geological bodies. Jingshan Group metamorphic rock served as the activator, Jiaodong Group partially provided ore materials, magmatism provided heat source for multiple ore-forming fluids, and fractures played the role of dynamics and location space. The precipitation of ore-forming materials usually occurred in the locations of abrupt change of the attitudes of fractures and the branching and compounding of different faults. Combined with the results of vertical zoning of gold grades and thickness mapping, this paper summarizes prospecting criteria, discusses the concentration rules of gold mineralization, and suggests that at the depth of -400～1000m in the northeast direction of No. 94 exploration line of No.Ⅰ2-2 ore body there may exist favorable prospecting potential.