Abstract：The Chagele Pb-Zn deposit is located in western Gandise-Nyainqentanglha metallogenic belt. Ore bodies are produced in the contact zone and rock fracture zones and controlled by the shape of granite porphyry and NE-NW trending faults, suggesting a typical skarn deposit. Zircon ICP-MS U-Pb weighted average age of granite porphyry is 63.18Ma ± 0.77Ma, and the geochemical characteristics of the rocks indicate melting-type granite formed in the collision environment. Preliminary studies show that the Chagele Pb-Zn deposit was genetically related to the collision of India–Asia continent and was formed at the main collision stage of steep subduction of Indian continent.