Abstract：Located in central Xuefeng Mountain arc structural belt, the Zhazixi W-Sb deposit is a typical vein deposit. The Sm-Nd isotope dating of scheelite from the Zhazixi W-Sb deposit was performed in this paper, and the result shows that the Sm/Nd ratios vary from 0.2175 to 0.3485. In the 147Sm/144Nd versus 143Nd/144Nd diagram, the scheelites show a good linear arrangement and yield an isochron age of 227.3±6.2 Ma (MSWD=1.6). The Sm-Nd age represents the formation age of the scheelite and can indicate that the W and Sb mineralization in Zhazixi district took place in late Triassic period. εNd (t) values of the samples vary from -11.81 to -11.91, quite different from the values of the Woxi W-Sb-Au deposit, indicating that the two deposits were derived from obvious different sources for ore-forming materials. This study is important for the study of the polymetallic resources in western Hunan Province, and also contributes to regional prospecting.