Abstract：The Jinchuan Cu-Ni deposit is one of the world-famous typical superlarge copper-nickel deposits. Based on the feasibility test of the integrated ore-prospecting work based on multiple geosciences information on the known profile, in combination with geological characteristics of the ore deposit, the authors determined geological, geochemical and geophysical ore-prospecting criteria and established a geological-geophysical-geochemical model for ore-prospecting work in the depth and the lateral areas of the Jinchuan Cu-Ni deposit. Based on this model, the authors carried out ore prognostic work in the depth and the lateral areas of the II ore district within the Jinchuan Cu-Ni deposit and found five target areas with ore-prospecting potential. In the No. 2 multiple information integrated anomaly zone of Type I target area, drilling verification revealed a concealed Cu-Ni ore body.