Abstract：Located in Northwest China, Uygur Autonomous Region of Xinjiang possesses rich land, metal minerals, coal, and oil and gas energy resources; nevertheless, its culture and economic development is not very satisfactory. Xinjiang has great potential in making contribution to the economic and sustainable development of China. What we should understand clearly is that the exploration and development of the mineral resources in Xinjiang is still not in a good arrangement, and the basic facilities and researches are lack of development policy and scientific arrangement as a whole. As the exploration and development of resources and energy are still at the initial stage in Xinjiang, the exploration depth remains rather shallow (i.e., in the first depth space of 0~500 m), and the exploration in the second depth space (500~2000 m) is highly demanded. The authors point out that earthquakes are very active in Xinjiang and there exists potential danger of strong earthquakes in the Tianshan earthquake belt. Nowadays, we should pay much attention to the introduction of advanced technologies and the cohesion of high-tech talents. That is to say, Uygur Autonomous Region of Xinjiang has only the necessary conditions but fails to have the sufficient conditions at present. To develop the economy and societiy in Xinjiang, we need the coupling and perfecting of both the necessary and the sufficient conditions. Therefore, the leapfrog development is not only the only way but also the power source to develop Xinjiang. On such a basis, this paper deals in brief with four aspects of problems for the purpose of the development of Xinjiang under the guidance of the national strategy demand and independent innovation suggested by the Central Committee of the Communist Party of China and the State Council:（1）The safe and stable strategy reserve base of the resources and the development of society and economy in western China;（2）The strengthening of the monitoring, prediction and resistance of earthquakes in Xinjiang and its adjacent areas;（3）The building of the Kashi business center and the marine-continental channel for exchange of science and technology, business and trade as well as culture crossing western Asia and Western Europe；（4）The strengthening of the systematic and harmonious culture contribution in Xinjiang.