The Yalu River Basin is a typical multicycle and multiplex basin, which is potentially rich in oil and gas resources. Guided by the method of tectonic geology and petroleum geology and based on geophysical and geological data analysis, the authors emphatically studied Changbai Depression in Yalu River Basin and made scientific evaluation of its resource assessment according to investigating the petroleum geological condition and structure characteristics of the study area. The results show that the central extensional subsidence belt of Changbai Depression in Yalu River Basin with large thickness and continuous stratigraphic sequence seems to be the preferred favorable exploration area, which has various local structures in favorable directional zone of hydrocarbon migration.