Located in the southwestern part of Gan-Hang tectonic zone and closed to the Xiangshan uranium orefield, the largest volcanic-type uranium orefield in China, the Yuhuashan area is a significant prospective prediction area for uranium ore deposit. In this paper, a systematic study of uranium metallogenic conditions such as metamorphic basement, magmation, fracture structure, and hydrothermal activity indicates that Yuhuashan area is an excellent potential area for uranium mineralizaiton. Compared with the Xiangshan uranium orefield, they have many great differences in such aspects as the degree of volcanic activity, the degree of late hydrothermal activity, and the denudation degree. The geochemical and geophysical anomalies of Yuhuashan area indicate that the area within the comprehensive anomaly of U -Th -Mo, the alternate magnetic positive and negative anomalies and positive radioactive anomalies are favorable areas for uranium exploration. Based on the ore-forming geological, geochemical and geophysical conditions, the authors established a comprehensive anomaly model and a uranium exploration model for Yuhuashan area, which will provide important theoretic and practical reference for uranium exploration in the future. Moreover, the authors hold that more exploration work should be preferentially carried out along the Weishan-Tongshan fault zone which is the key position of resource reserves.