Kalatag area of Xinjiang is located in the east Tianshan metallogenic belt, where mineral resources are abundant, and copper, gold and polymetallic ore deposits have great prospecting potential. Copper and gold mineralization and surface mineralized alteration phenomena are obvious, and limonite mineralization + jarosite + sericitization assemblage has formed abnormal spectral reflectance characteristics, which are favorable for the utilization of hyperspectral remote sensing ground-air integrated prediction method to detect copper and gold mineralization alteration information. In this paper, the authors carried out air high spectrum and ground spectrum in search for copper gold polymetallic deposits. HyMap aviation imaging spectrometer and FieldSpec Pro FR spectrometer were adopted and, as a result, HyMap aviation high spectral resolution data, ground quasi-synchronization calibration data and ground hyperspectral data were obtained in the study area, whereas extracting and filtering were conducted based on HyMap aerial hyperspectral image of metallogenicl favorability alteration information. On such a basis, the air-ground hyperspectral comprehensive analysis was made for the Hongshan copper and gold deposit in the study area and, in combination with the geological background of the deposit, a hyperspectral remote sensing ground-air integrated prospecting model was established for the Hongshan copper gold deposit. On the basis of comparison and analysis, two prospecting targets were delineated. The application of hyperspectral remote sensing ground-air integrated prediction method in the study area shows a good application effect.