The Zhuyuangou molybdenum deposit was newly found in the East Qinling-Dabie Mountain metallogenic belt. It is estimated that the amount of molybdenum metal is 95.9 thousand ton, with the average grade being 0.10%,reaching medium-sized reserves. The discovery of this deposit is a new progress in the prospecting for molybdenum deposits in the inner part of the late Yanshanian granite mass.The Zhuyuangou granite mass is a part of the Taishanmiao granite batholite,and possesses the features of A-type granite characterized by later intracratonic orogenesis in an extensional environment.The orebody occurs in the inner contact zone of the third intrusive syenogranite-porphyry and the first intrusive medium-coarse syenogranite of late Yanshanian period. It exhibits stratoid or lenticular form, suggesting a porphyry molybdenum deposit. Through a comprehensive analysis of the metallogenic geological conditions and geochemical anomaly characteristics,the authors carried out prospecting work step by step and, through repeated understanding and practice, finally made the breakthrough. Based on geological characteristics of the molybdenum deposit,the authors summed up the following key prospecting positions:(1) area of molybdenum 1:50000 geochemical anomaly in late Yanshanian granite mass;(2) superposition of different scales of Mo geochemical anomalies;(3) basically parallel small faulted structural zones and fissure-developed or crowded zones which are consistent with regional NEtrending fault; (4) around the inner contact zones of the different intrusive bodies of late Yanshanian Taishanmiao A-type granite; (5) Genetically, it belongs to porphyry molybdenum deposit. The discovery of this deposit provides new training of thought for the prospecting work in the East Qinling-Dabie Mountain metallogenic belt.