China Regional Geochemical Exploration Database is the first one of its kind that synthesizes the testing data of 39 elements and their oxides from the regional geochemical exploration respectively at scales of 1:200, 000 and 1:500, 000, covering 28 provinces (autonomous regions and municipalities directly under the central government). It features nearly 55.4 million pieces of data collected from 1.42 million data points. The data involves 1, 299 map sheets at scale of 1:200, 000 and 18 map sheets at 1:500, 000. It is China's first massive geochemistry database. The national mineral resources potential evaluation project updated the database, making the national geochemical exploration database cover over 1.47 million records of aggregated data, with the data reaching 63.21 million records. On this basis, more than 40, 000 geochemical maps have been compiled, and a spatial database has been established to provide rich geochemical information for carrying out geochemistry research and predicting mineral resources. This pioneering work is of great significance to improve the level of geochemical exploration and research in China. It provides the most fundamental data for studying regional geochemical distribution of metallogenic elements, ecological environment, and basic geology, as well as for mineral resources prospecting throughout China.