The Lianhuashan fault zone is not only an important NE-striking fault zone in Guangdong Province but also a significant tin, tungsten, copper, lead-zinc polymetallic metallogenic belt. Based on geological field observation of the Lianhuashan fault zone and the typical mining area as well as the measurement of the zircon U-Pb age of the granite intrusive with ductile deformation, the authors preliminarily investigated the time of ductile deformation and boundary fault and the relationship between deformation and mineralization in this paper. The result indicates that the ductile deformation time in the Lianhuashan fault zone is around 129-127 Ma, and the brittle boundary fault was developed between the sedimentary time of Guancaohu Formation and the Heshui Formation. The age of ductile shear deformation in the Lianhuashan fault zone was earlier than the mineralization time, and the ductile shear deformation provided the ore-bearing space for mineralization.