This paper is the result of mineral exploration engineering.[Objective] The East Nanling region is an important concentration area of Li-Be-Nb-Ta polymetallic deposits, and the potential of Li-Be-Nb-Ta mineral resources is huge. The main types and prospecting breakthrough of Li-Be-Nb-Ta deposits are the key issues to be urgently solved in this area. [Methods] Based on the investigation of tungsten, tin, rare and rare earth minerals, we systematically summarizd the conditions of regional metallogenic geological, geochemical and geophysical achievements and remote sensing, and latest achievements of prospecting in the east Nanling. [Results] It is proposed that the large-scale mineralization of Li-Be-Nb-Ta deposits in this area during the Yanshanian and Caledonian periods. We proposed that the main prospecting deposit types of Li-Be-Nb-Ta deposits are muscovite (lepidolite) albite granite-type related to Yanshanian highly differentiated granite, and pegmatite-type related to Late Caledonian granite. 11 prospecting areas for Li-Be-Nb-Ta deposits and 20 prospecting target districts (including 6 A-level, 6 B-level and 8 C-level) have been delineated. [Conclusions] It is suggested that the 6 A-level prospecting target areas should be given priority to carry out mineral exploration work, in order to achieve new major breakthroughs in the prospecting of Li-Be-Nb-Ta deposits in the East Nanling region as soon as possible.