Abstract: The Huangtian Pb-Zn deposit occurs along the contact zone between the carbonate rocks of lower Permian and Emeishan basalt of upper Permian. Orebodies are mainly bedded and lenticular in form. The ore minerals are mainly sphalerite and galena, whereas the gangue minerals are quartz, calcite and dolomite primarily. The composition of C and O isotopes of the hydrothermal calcite indicates that the carbon of CO₂ in the ore-forming fluid is pluralistic, mainly from the mixed carbon of the mantle source and the marine carbonate rocks. The sulfur isotope composition of sulfide indicates that the sulfur in the lead-zinc deposit is dominated by magmatic sulfur and may be mixed with other sulfur sources (possibly including formation sulfate). The lead isotopes indicate that the metallogenic material mainly came from the surrounding rock. The lead isotopes indicate that the metallogenic material mainly came from the surrounding rock, basalt and Yanshanian granite, which is the product of multisource mixing. Isochron age of Rb-Sr isotope is (83.2±3.4) Ma, indicating the formation of the lead-zinc deposit in the late Yanshanian period. The metallogenic dynamic background of the Huangtian Pb-Zn deposit might have been related to the large-scale lithospheric extension of the Youjiang fold belt at the end of Mesozoic. The Late Permian marine eruption volcanic rocks played an important role in the formation of lead and zinc deposits in the aspect of cover and ore-bearing layer and mineralization. All the geochemical information suggests that the source of ore-forming metals and fluids of the Huangtian Pb-Zn deposit was mixed product. The type of the deposit is sedimentary and reformed deposit.