Abstract: The 1∶50 000 mineral geological survey of Shixia Map-sheet (I48E014014) in Gansu Province was conducted according to the Technical Requirements of Solid Mineral Geological Survey (1∶50 000) (DD2019−02) issued by the China Geological Survey. During this survey, the digital mapping technique was employed to carry out 1∶50 000 mineral geology-specific mapping, comprehensive mineral inspection, and prospecting prediction and to delineate prospecting target areas based on the systematical collection and comprehensive analysis of existing geological, geophysical, geochemical, remote sensing, and mineral data. The geology-specific mapping was completed by field mapping and indoor map compilation. As a result, the Shixia Map-sheet was divided into 19 types of informal sedimentary suites and one type of intrusive rock suites. Meanwhile, the mineral information cards were filled in combination with comprehensive mineral inspection of major survey sites in the Map-sheet area. On these bases, typical deposits in the Map-sheet area were researched and metallogenic factors were summarized. Moreover, the result maps such as 1∶50 000 mineral geological map, metallogenic regularity maps, and mineral prediction maps were prepared, and a database of these maps was developed. In the result maps and database, metallogenic suites, regional structures, and mineralized alteration are highlighted, metallogenic factors in the Shixia Map-sheet are systemically summarized, the metallogenic models of typical deposits are established, and seven prospecting and prediction targets of medium-low temperature hydrothermal gold deposits was delineated.