Abstract：The Liguifu tungsten-tin polymetallic deposit occurs in the east of Dupangling granite, being mainly of the greisen-quartz vein type. The precise Re-Os isotope dating of molybdenite from the ore shows that the isochron age is (211.9±6.4)Ma (n=7，MSWD=4.1), and the weighted average of model ages is (213.3±2.9) Ma (MSWD=4.0). The isochron age suggests that mineralization took place in the Indo-Chinese epoch, and the result demonstrates that Early-Mesozoic tungsten-tin polymetallic mineralization did happen in Dupangling area.