Xuancheng area in Anhui Province is an important part of the metallogenic belt in the middle and lower reaches of the Yangtze River, with the surface characterized by Quaternary coverage, red bed coverage and nappe structure. Based on the newly acquired 1:50,000 high-precision gravity and magnetic data, the plane properties of the geological structure, ore-control horizon, and intrusive rock mass are obtained through the plane interpretation to the study area. Based on the magnetic second-degree and half-dimensional quantitative inversion results, we explored the three-dimensional structure of the whole area, and obtained the geometric spatial distribution rules of the main ore-controlling faults, magmatic rocks, and ore source layers. Also, we studied the spatial attributes of the favorable parts of metallogenesis. Starting from the known typical deposits in the study area, we summarized the mineralization factors of the geophysical characteristics, metallogenic conditions, and ore-controlling factors. We also explored the geological-geophysical prospecting model of the target area, divided the prospecting mineralization areas, and delineated the key prospecting target areas. The drilling to cores of Weidun target area in Zhuqiao Metallogenic Prospecting Area shows that, by processing the 1:50000 high-precision gravity and magnetic data, we implemented a way, including the potential field plane-threedimensional exploration and geological-geophysical prospecting model construction, in mineral exploration, which taked advantage of the geophysical prospecting and finally improved the exploration effect. The results in this study can provide references for prospecting and exploration works in eastern China.