[Objective] To improve the supply security of Cu-Ni-Co resources in China, it is necessary to sort out the mineralization regularity and prospecting indicators of the magmatic copper-nickel-cobalt sulfide deposit in the Phanerozoic in the Eastern Kunlun orogenic belt on the northern margin of the Qinghai-Tibet Plateau. [Methods]The geological, geochronology, geochemistry, and geophysical characteristics of five stages mafic?ultramafic complexes including the Late Ordovician?Early Silurian, the Middle Silurian?Middle Devonian, the Early Carboniferous, the Middle Permian?Early Triassic, and the Middle?Late Triassic are summarized. [Results] Based on the above work, the source area properties of magmatic copper?nickel deposits and their relationship with the highpressure?ultrahighpressure eclogite and the evolution of Proto?Paleo Tethys were discussed. The influence of crustal sulfur contamination and crystal differentiation on sulfide saturation was analyzed. The rules of the optimal location of copper-nickel ore bodies were summarized. The typical differences between the ore-forming mafic-ultramafic complexes and the no-ore mafic-ultramafic complexes were described. [Conclusions] At last, a comprehensive information exploration model was established.