Abstract：With the ETM + image as the information source in southern Yongzhou area, two ore-prospecting parameters of remote sensing, i.e., advantage grade of fault structure and alteration mineral information, were built through the information extraction, visual interpretation and quantitative analysis. W, Sn, Cu, Pb and Zn elements in the working area were chosen to perform data-processing, correlation-analyzing and factor-analyzing and, as a result, the map of geochemical property and spatial distribution of metallogenic elements was drawn and geochemical exploration parameters were built. On the basis of the GIS platform, the ore-forming characteristics and mutual relationships of the prospecting factors were revealed through multi-source information fusion, analysis and visualization in combination with geological, remote sensing and geochemical exploration methods for multi-source information fusion, source analysis and visualization of the prospecting parameters. A set of multi-source information comprehensive prospecting technologies was established, which is helpful to predicting ore resources and optimizing metallogenic target areas.