Abstract: The metallogenic model and prospecting criteria of sedimentary bauxite deposits in Central Guizhou-South Chongqing region are summarized as follows: Guangxi movement?took place at the end of the Silunian and Ziyun movement that occurred at the last stage of the?Devonian period, which might both have been in the crust-mantle interaction phase of the E’mei mantle plume evolution. The transportation of a large amount of materials and radiation energy from the?mantle plume to the crust led to the rise-and-fall movement of the earth’s crust. During this period, large area of the region ??was uplifted, leading to the formation of the long-term uplifted area. At the end of the Devonian, the pediplanation occured. In the Early Carboniferous Yanguanian period, the climate?was?humid and rainy. Exposed surface?rock in the Lower Paleozoic experienced laterization and calc-laterization. Laterite weathering crust with gibbsite provided sources for the sedimentary bauxite. In Xiuwen and Xifeng-Zunyi sedimentary areas, the bauxite-bearing rock series of Jiujialu Formation formed at the Early Carboniferous Datang Stage. Suiyang-Zheng’an-Daozhen sedimentary area deposited bauxite ore-bearing rock series of the Dazhuyuan Formation in the Maping period which, after the formation of the limestone of the Late Carboniferous Huanglong Formation, generated calc?laterization. As the deposition region formed different parent rocks containing gibbsite-laterite weathering crust, the deposited bauxite ore-bearing rock series have different chemical and mineral compositions.