The dataset of 1∶50 000 mineral resource potential assessment of the gold-antimony deposit integrated exploration area in Yawan-Daqiao Area, Gansu Province (also referred to as the Dataset) includes comprehensive suite-structure maps, metallogenic factor maps, predictive factor maps, prediction result maps, among others. During the development of the Dataset, the suites and structures in the integrated exploration area were collated using the latest data. Meanwhile, focusing on gold and antimony deposits, the Daqiao gold deposit, Pingding gold deposit, and Yawan antimony deposit in the integrated exploration area were studied based on the “trinity” prospecting prediction theory of exploration areas that integrates metallogenic geological bodies, metallogenic structures, metallogenic structural planes, and metallogenic characteristics and indicators. As a result, the genetic types and predication types were classified, the regional metallogenic regularity was summarized, and the regional predication models were established. Furthermore, 42 predicted minimum prospecting target areas were delineated, with predicted gold and antimony resources of 560 774.59 kg and 737 241.43 tonnes, respectively. The development of the Dataset provides a demonstration of 1∶50 000 mineral resource potential assessment of integrated exploration areas. Meanwhile, relevant research ideas, working methods and processes, expected results, and result presentence were summarized and explored. Therefore, this Dataset will provide certain references for similar potential assessment.